Pepsin

What is this enzyme?

Pepsin is a digestive enzyme produced in the stomach that breaks down proteins into smaller peptides. It is secreted by the stomach lining as an inactive precursor called pepsinogen, which is then activated by the acidic environment in the stomach. Pepsin plays a crucial role in the digestive process by initiating the breakdown of dietary proteins, making them easier to further digest and absorb in the small intestine.

Why do I have deficiency?

A pepsin deficiency can occur due to various factors, including chronic stomach conditions like gastritis or atrophic gastritis, which reduce stomach acid production and impair pepsin activation. Long-term use of antacids or proton pump inhibitors (PPIs) can also lower stomach acidity, hindering pepsin activation. Additionally, surgical removal of part or all of the stomach (gastrectomy) can lead to reduced production of pepsinogen. 

What can I do about it?

Addressing pepsin deficiency involves managing underlying conditions that affect stomach acid production. If antacids or PPIs are used, it should be stopped. Supplementing with betaine HCl under medical supervision may aid in increasing stomach acidity and promoting pepsin activation. Additionally, digestive enzyme supplements containing pepsin can be considered to support protein digestion.