S-adenosyl L-methionine (SAMe)

What is S-adenosyl L-methionine (SAMe)?

S-adenosyl L-methionine (SAMe) is a naturally occurring compound found in the body that plays a vital role in methylation processes, which are crucial for producing neurotransmitters and maintaining cellular health. It is often used as a dietary supplement to support mood, joint function, and liver health. SAMe is available in various forms, including tablets and capsules, and is particularly popular for its potential antidepressant effects.

Why do I have an intolerance?

Some individuals may experience intolerance to SAMe, resulting in gastrointestinal symptoms such as nausea, diarrhea, and abdominal discomfort. These reactions can stem from individual sensitivities or the compound's effects on serotonin levels. In some cases, users may also experience headaches or anxiety.

What can I do about it?

If you suspect an intolerance to SAMe, consider discontinuing its use and monitoring your symptoms. Alternatives that may support mood and joint health include omega-3 fatty acids, L-tryptophan, or curcumin. Gradual reintroduction of SAMe at lower doses might help assess your tolerance level and determine if you can safely incorporate it back into your regimen.